Our researchers are conducting research to translate laboratory sciences into the most precise treatment options for patients with solid tumor cancers. One strategy involves developing tools to detect patterns in cancer development, progression and treatment response such as HIDRA, a database containing thousands of medical records and tissue inventories maintained by Cancer Consortium partners, Fred Hutch, UW Medicine, Seattle Children's and Seattle Cancer Care Alliance. Researchers and clinicians will be able to explore the database to identify patient backgrounds, behavior, genetics, treatment and response, and translate these findings into better therapies, ultimately improving outcomes for our patients.
The UW's Oncoplex is a multi-marker cancer sequencing test capable of analyzing hundreds of genes simultaneously for mutations. The team has characterized mutations known to cause cancer variants for which a highly-effective therapy is available. Learn more by watching this video.
UW Medicine's Center for Cancer Innovation (CCI) give patients with advanced cancer access to the very latest research. The CCI includes more than 70 members from nearly a dozen institutions, including UW Medicine, Fred Hutch, University of California, Santa Cruz, Seattle Cancer Care Alliance, the Institute for Systems Biology, Northwest Medical Specialties and other private oncology practices and data analytics companies. Together, these dedicated researchers and physicians plan to approach cancer treatment using an "all for one" approach.
Personalized medicine uses a patient’s individual genetic and genomic information to design treatments that are targeted and effective. A person’s genetic variation may predispose an individual to cancer by encoding specific mutations in their DNA. Importantly, specific mutations also signal which tumors are likely to respond to certain therapies.
This knowledge can lead to individualized precision oncology treatments designed to maximize the likelihood of success by avoiding therapies that won’t work on specific cancer types. By merging a patient’s clinical data with the patient’s genetic and genomic molecular data, the goal of precision oncology is to design targeted therapies that more accurately and precisely treat a patient’s unique cancer profile.
Deoxyribonucleic acid (DNA) is a molecule that records our genetic code and contains all of the instructions to build our bodies. An organism’s complete set of DNA is called a genome and is built of linear sequences of four DNA nucleotides, or bases. We call specific series of bases genes, which may code for features such as hair color, or whether you will be right or left handed.
If any of these bases gets out of order on the DNA strand, this is a mutation. Most mutations are harmless, but some inherited variants can put people at higher risk for developing cancer. Further, some mutations are particularly susceptible to certain drugs, leading to targeted therapy.
Got ideas for better, faster cancer cures?
April 15, 2016 | Mary Engel / Fred Hutch News Service
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April 11, 2016 | Susan Keown / Fred Hutch News Service
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Obama's precision medicine initiative catches up to, spurs cancer research
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Fred Hutch recruits D. Gary Gilliland as its new president and director
Nov. 20, 2014 | Fred Hutch News Release
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Nov. 16, 2014 | By J.M. Kocarnik/Science Spotlight
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UW Medicine magazine Fall 2014
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June 3, 2014 | By Dr. Sabrina Richards/Fred Hutch News Service
Seattle Cancer Care Alliance Proton Therapy, A ProCure Center Appoints Dr. Ramesh Rengan as Medical Director
Jan. 29, 2014 SCCA News Release
Genomic Medicine at the University of Washington
UW Medicine Winter 2010
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Seattle Cancer Care Alliance
Amanda Paulovich, oncologist and cancer geneticist
Fred Hutch Featured Researcher Profile