The Myelodysplastic syndromes (MDS) and Myeloproliferative neoplasms (MPN) Program is a highly interdisciplinary group of investigators dedicated to reducing the incidence and subsequent mortality of MDS/MPN. The program fosters interdisciplinary research in basic science, genetics, clinical medicine, cancer prevention, and epidemiology at Fred Hutch, the faculty at the University of Washington, and the clinical community to improve MDS/MPN prevention, detection, diagnosis and treatment.
Forty years ago, researchers at Fred Hutch developed bone marrow transplantation, which continues to be an effective option for patients with MDS and MPN. Dr. E. Donnall Thomas and his team proved it is possible to replace cancerous cells and stem cells with donated healthy cells that engraft within a patient’s bone marrow. The discovery has created an effective option for many blood cancers, and earned Thomas the 1990 Nobel Prize in physiology or medicine.
Dr. Press is a medical oncologist with a primary interest in developing novel immunotherapies for treatment of hematologic malignancies using monoclonal antibodies, immunotoxins, radioimmunoconjugates, antibody-drug conjugates, adoptive T cell therapy, and antibody-targeted therapy with nanoparticles and siRNA. His research involves genetic engineering of antibody derivatives as well as experiments with cell lines, mouse tumor models, and human clinical trials of novel agents for lymphomas, leukemias, and multiple myeloma.