Oncoscape is developed at the Fred Hutchinson Cancer Research Center under the auspices of the Solid Tumor Translational Research initiative.
To build Oncoscape, STTR established a cross-disciplinary team to connect some of the most challenging aspects of information sharing, from collecting and analyzing samples so researchers could conduct smarter studies, to creating visualizations for clinicians to easily interact with data.
Eric Holland, MD, PhD
Director, Human Biology Division, Fred Hutch
Professor of Neurological Surgery, Chap and Eve Alvord and Elias Alvord Chair in Neuro-Oncology, and Director, Nancy and Buster Alvord Brain Tumor Center, UW Medicine
Director, Seattle Translational Tumor Research, Fred Hutch
Dr. Holland is a world-renowned physician-scientist who combines compassionate patient care with exacting laboratory research to discover more effective treatments for brain tumors. As a neurosurgeon, Dr. Holland specializes in caring for patients with glioblastomas, the most common malignant brain tumors in adults. He is committed to finding targeted treatment options for this aggressive cancer, which currently has few effective therapies. He continues to foster productive collaborations to spark discovery and advance precision oncology. He believes Oncoscape has the potential to transform patient treatment. Using this tool, researchers can now begin to group tumors by their genetic profiles to help physicians select therapies likely to work best for each patient.
Lisa McFerrin, PhD
Bioinformatics project manager, Seattle Translational Tumor Research, Fred Hutch
Dr. McFerrin specializes in the development of software and methods that bridge genomic and clinical data to advance the understanding of cancer biology and improve patient care. In her role as bioinformatics project manager within STTR, she designs tools that facilitate collaborative and reproducible research in order to lower the barriers in communication, analysis, and sharing of data, knowledge and methods. As an expert in bioinformatics, Dr. McFerrin applies mathematical and computational principles to understand large-scale biological data. Her background in such disciplines as computer science, mathematics, statistics and biology enables her to analyze data from genome sequences and clinical records to uncover novel, meaningful insights from datasets otherwise too complex to examine manually. Dr. McFerrin plays a key role in the development of Oncoscape, open-source software that helps scientists integrate information from molecular research in the laboratory with patient records and clinical studies. Her research includes the study of proteins that are involved in normal cell growth and metabolism but can also play a significant role in the development of cancer.
Hamid Bolouri, PhD
Research Member, Human Biology Division, Fred Hutch
Dr. Bolouri tackles big data, developing computational methods to discover how genes control the behavior of cells in health and disease. Dr. Bolouri’s discoveries include the first genomic model of how roughly 150 genes drive the development of a type of immune cell called a T cell, as well as the first model to reveal how a specific network of interacting genes controls early embryonic development in the sea urchin. Dr. Bolouri has contributed to the development of more than a dozen software platforms, including Oncoscape. He is collaborating with Fred Hutch colleague Dr. Soheil Meshinchi to identify key molecular changes in childhood acute leukemia that can be used to guide therapy. With Dr. David MacPherson, Dr. Bolouri is studying the role that a specific regulatory gene plays in lung cancer. As part of STTR, Dr. Bolouri has developed methods to sift through large amounts of clinical and molecular data to find patterns that can be used to tailor treatment and improve precision medicine strategies.
Research Technician/Cloud Architect, Seattle Translational Tumor Research, Fred Hutch
Software Developer Engineer, Seattle Translational Tumor Research, Fred Hutch
Ms. Krenn started her research career on the bench and eventually moved to a program management roll assisting in the establishment of a central tissue repository for several national clinical trials. During her time in tissue banking she managed several SQL research databases. Motivated by the massive amounts of data being generated she began to further develop her programming skills to focus on front-end development and data visualization. On the Oncoscape team her education, research and software development background help to understand the limitations we face as researchers and guide to establish relevant cloud based solutions for the center.
Software Engineer, Seattle Translational Tumor Research, Fred Hutch
Mr. Zager has been crafting digital strategies and executions for the past 15 years. He has served in leadership roles at several notable experiential and digital agencies and partnered with bio-tech, start-up and Fortune 500 companies such as Proctor & Gamble, Toyota and Coca-Cola. Prior to joining the Fred Hutch, Michael was responsible for evolving and supporting all digital marketing platforms in T-Mobile’s retail stores. Michael’s passionate for transforming people’s lives with cutting edge technology lead him to the Fred Hutchinson. Today, he contributes enterprise architecture, software development best practices and big data expertise to Oncoscape.
IT Solutions Architect, Center IT, Fred Hutch
Mr. McDermott started his career at the Fred Hutch in 2000 as an IT professional in Center IT. During that time, he has been involved with the design, implementation and administration of many IT systems including email, server virtualization, storage, cloud computing and more. He’s most interested in working on projects that have a direct and positive impact on the important research that is happening at the Center.
Mr. Shannon spent his twenties as a carpenter, eventually returning to college to prepare for a second career as a scientific programmer. He subsequently worked in a variety of disciplines: atmospheric chemistry, psychoacoustics, mechanical engineering, radio astronomy, then realized his long-held aspiration to work in biology and medicine by joining the ISB in 2001. He recently spent four years at the Fred Hutch in the Bioconductor and the Solid Tumor Translational Research projects including Oncoscape.